Autoimmunity Care Histazyme Care is a comprehensive nutritional formulation designed to support dietary histamine breakdown, mast-cell balance and healthy histamine metabolism. It combines 20,000 HDU of Diamine Oxidase (DAO) with Quercetin, Vitamin C, Riboflavin B2 and Magnesium Glycinate to provide multi-nutrient support for individuals who experience food-related histamine symptoms.

Key Benefits
• Supports Dietary Histamine Breakdown - DAO helps break down histamine present in food within the gastrointestinal tract, supporting better management of dietary histamine load.
• Supports Mast-Cell Balance - Quercetin provides nutritional support for healthy mast-cell activity and histamine release regulation.
• Supports Histamine Metabolism - Vitamin C, riboflavin and magnesium complement DAO with broader nutritional support for healthy histamine handling.
• Helps Support Food Tolerance - Provides targeted nutritional support for individuals who experience recurring symptoms after consuming histamine-rich foods.
• Provides Antioxidant & Cellular Support - Quercetin and vitamin C contribute antioxidant support to help maintain healthy cellular responses.
 
Key Ingredients
• Diamine Oxidase (DAO) – 20,000 HDU - Supports the enzymatic breakdown of dietary histamine in the gut before it is absorbed.
• Quercetin Dihydrate – 250 mg - A naturally occurring flavonoid with antioxidant and inflammation-modulating properties. Supports healthy mast-cell responses and may help regulate histamine release.
• Vitamin C (Coated) – 200 mg - Provides antioxidant support and supports DAO enzyme activity and histamine degradation.
• Riboflavin (Vitamin B2) – 10 mg - Provides nutritional support for normal cellular energy metabolism and acts as an essential cofactor for histamine metabolism.
• Magnesium Bisglycinate – 100 mg - Supports DAO synthesis, nervous-system function, muscle function, and overall physiological balance.

Key Indications
Useful for individuals experiencing:
• Histamine intolerance / suspected dietary histamine sensitivity
• Food-related flushing, itching, or skin reactions
• Headaches or migraines associated with certain foods
• Bloating, abdominal discomfort, or digestive symptoms after histamine-rich meals
• Reactions to fermented foods, aged cheese, processed, or leftover foods
• Symptoms associated with mast-cell reactivity
• Histamine-related symptoms overlapping with IBS or SIBO
• Multiple food sensitivities with no clear IgE-mediated allergy
• Seasonal or environmental allergy-related histamine burden
• Individuals requiring dietary histamine support as part of a broader functional medicine protocol

Recommended Dosage
Take 1–2 capsules before meals or before consuming histamine-rich foods, or as directed by your healthcare professional.

Why Choose this Product?
• 20,000 HDU of DAO per capsule for targeted dietary histamine support.
• Combines DAO + Quercetin + Vitamin C + Riboflavin B2 + Magnesium in one formulation.
• Complete histamine intolerance formula.
• Plant-based.

References
Schnedl WJ et al. (2019). https://pubmed.ncbi.nlm.nih.gov/31258986/
Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Science & Biotechnology
Shaik YB et al. (2006). https://pubmed.ncbi.nlm.nih.gov/16934259/
Role of quercetin in allergy and mast cell stabilisation. European Journal of Pharmacology.
Maintz L, Novak N. (2007). https://pubmed.ncbi.nlm.nih.gov/17490952/
Histamine and histamine intolerance. American Journal of Clinical Nutrition.
Wöhrl S et al. (2004). https://pubmed.ncbi.nlm.nih.gov/15637210/
Diamine oxidase supplementation improves symptoms in patients with histamine intolerance: A pilot study. Journal of the American College of Nutrition