Baicalein is a flavonoid compound that has antioxidant and anti-inflammatory properties on the brain microglia cells.It can cross the BBB.It has neuroprotective properties to dopaminergic neurons implicated in the pathogenesis of Parkinson's disease. Baicalein protects cortical neurons from beta-amyloid the protein involved in Alzheimer's disease. Baicalein protects neurons from decreased blood flow to the brain.